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30 November 2011

Battle of the Sex Hormones

No, this isn't about fighting hormones - this about the two main sex hormones: testosterone and oestrogen (or estrogen) - the "male" and "female" hormones respectively.

Now, I know that not everyone knows that these hormones are not restricted by gender - one episode of Charmed made the mistake of having two coroners shocked that the female "corpse" had testerone in its system [facepalm]- so I'll give a quick summary here:

Testosterone - male body produces 10 times more than the female, but the female body is more sensitive to it.
Effect in males: Developes testis and prostate; promotes increased muscle, bone mass, deeper voice, and body hair; too much results in aggressive behaviour and atropy of the testes; lowers during fatherhood; makes organs like the heart and liver bigger.
Effect in females: Regulates menstrual cycle.
Effect in both: Essential overall health, and prevents oesteoporosis. Too much in females will produce some of the male results. Mental affects include higher risk tolerance, and higher levels are speculated to ward off dementia and Alzheimer's Disease. There are also suggestions of a "curvilinear or even quadratic relationship between spatial performance", as well as relations to attention-span and memory.

Oestrogen - there are three main types (estrone (E1), estradiol (E2), and estriol (E3)) which are active during menopause, non-pregnant/non-menopasusal stages, and pregnancy. So, the big one is estradiol.
Effect in males: Low levels are speculated to cause OCD, too much will give men breasts and lower libido; increases in sympathetic pregnancy; used to treat prostrate cancer in certain situations.
Effect in females: Develops breasts, hips, regulates fertility (ovulation); promotes finer hair and smoother skin; low levels lead to poor mental health; once breast cancer is established, high levels feed it; increase fat stores; accelerate metabolism; reduce muscle mass;
Effect in both: Helps wound healing. Too much in males will produce some of the female results.

Admittedly oestrogen doesn't appear to play that great a part in male bodies but it's there.
I could stop here but the actual reason I wanted to bring this up was because I was rewatching a couple of my favourite episodes of House: Skin Deep and Act Your Age. In these two episodes the hormones of oestrogen and testosterone feature as the central players. I rather like House as it accurately portrays medical disorders and I get to watch an intelligent jerkass prove why he's the best doctor.

Every fetus is a girl to begin with and then depending on if it is XY or XX, it will then change internally - the male/female hormones of testerone/oestrogen will then give the fetus secondary sexual characteristics, like the testes dropping in males.

In Act You Age the two child patients are suffering from "Precocious puberty" due to too much testosterone from a certain, ahem, "medication" their father is taking. The symtoms in the boy are extreme aggression and a heightened libido - which results in the rather amusing incident of an 8 year old pinching the female doctor's bottom and tackling (and biting) the male doctor out of jealousy.
The little girl, 6 years old, I think, gets her period, hair in places, double vision, hot flashes, and a stroke - basically the symptoms of an old woman.

What can be said for the girl is that she got puberty with none of the femininity and then proceeded to get all the symptoms of a post-menopausal woman - because there is no oestrogen here. In the boy's case he is now "macho", kind of like an animal when you think about it - territorial towards "his" females to the point of violence. It's okay, I talk about oestrogen bad points next.

In Skin Deep the patient is a 15 year old female model, who is revealed to have cancer on her left testes. Yep, she is in fact a male - one who suffers from pseudo-male-hermaphroditism due to Androgen Insensitivity Syndrome. I mentioned that everyone is born as a girl and then they change; in this case the child is insensitive to testosterone and hence doesn't make the big changes. They still get testes but they don't drop and they don't develop in a male way. Instead they are entirely oestrogen, even more feminine than women. Perfect skin and shape and they never get a period.
However, just like testosterone, there are mental effects - in the case of too much oestrogen while the patient was docile, she was as manipulative as hell. This sort of figure appears in literature as the femme fatale, or the "seductress" in the Three Faces of Eve.

I'm not entirely sure why I wrote up this note but I find it amusing on how the extreme effects of each sex hormone on their main gender results in the undesirable literary archetypes of the possessive violent male and the manipulative vamp, who, traditionally, always lose to the main character or never get the boy/girl.

I dunno, maybe it's everything in moderation making its way to the surface in a strange way - funny since these archetypes appeared before people even knew about these hormones and their effects.

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